Biochem/physiol Actions
Reversible: no
ID50 = 500 nM against COX-1
Product does not compete with ATP.
Cell permeable: yes
General description
An active metabolite of the non-steroidal anti-inflammatory drug Sulindac (Cat. No. 574100). Inhibits Ras signaling. Strongly inhibits Ras-induced malignant transformation and Ras/Raf-dependent transactivation. Also decreases the Ras-induced activation of c-Raf-1 kinase. Inhibits cell growth and induces apoptosis in a time-and dose-dependent manner. Selectively inhibits prostaglandin H synthase-1 (PGHS-1; COX-1; ID50 = 0.5 µM) relative to prostaglandin H synthase-2 (PGHS-2; COX-2; ID50 = 14 µM). Reduces Aβ42 production independently of COX inhibition.
A cell-permeable, active metabolite of Sulindac (Cat. No. 574100). Strongly inhibits Ras-induced malignant transformation and Ras/Raf-dependent transactivation. Also decreases the Ras-induced activation of c-Raf-1 kinase. Inhibits growth and induces apoptosis in prostate cancer cell lines. Selectively inhibits COX-1 (ID50 = 500 nM) compared to prostaglandin H synthase-2 (PGHS-2; COX-2; ID50 = 14 µM). Preferentially inhibits the secretion of Aβ42 in CHO cells stably transfected with both APP75, and the PS1 mutant M146L.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Weggen, S., et al. 2001. Nature414, 212.Lim, J.T., et al. 1999. Biochem. Pharmacol. 58, 1097.Herrmann, C., et al. 1998. Oncogene 17, 1769.Picariello, L., et al. 1998. Eur. J. Pharmacol. 360, 105.Arber, N., et al. 1997. Gastroenterology 113, 1892.Meade, E.A., et al. 1993. J. Biol. Chem. 268, 6610.
Packaging
5 mg in Plastic ampoule
Warning
Toxicity: Harmful & Carcinogenic / Teratogenic (E)
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